Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review

Tohada M Al-Noshokaty; Abdallah Mansour; Rehab Abdelhamid; Nourhan Abdellatif; Ayat Alaaeldien; Tasnim Reda; Nourhan M Abdelmaksoud; Ahmed S Doghish; Ahmed I Abulsoud; Shereen Saeid Elshaer

doi:10.1016/j.prp.2023.154438

Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review

Pathol Res Pract. 2023 May:245:154438. doi: 10.1016/j.prp.2023.154438. Epub 2023 Apr 6.

Affiliations

¹ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
² Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt. Electronic address: [email protected].
³ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt. Electronic address: [email protected].
⁴ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Girls), Al-Azhar University, Nasr, Cairo, Egypt.

PMID: 37043965
DOI: 10.1016/j.prp.2023.154438

Abstract

Pancreatic cancer (PC) is one of the deadliest cancers associated with poor prognosis. The lack of reliable means of early cancer detection contributes to this disease's dismal prognosis. Long non-coding RNAs (LncRNAs) are protein-free RNAs produced by genome transcription; they play critical roles in gene expression regulation, epigenetic modification, cell proliferation, differentiation, and reproduction. Recent research has shown that lncRNAs play important regulatory roles in PC behaviors, in addition to their recently found functions. Several in-depth investigations have shown that lncRNAs are strongly linked to PC development and progression. Here, we discuss how lncRNAs, which are often overlooked, play many roles as regulators in the molecular mechanism underlying PC. This review also discusses the involved LncRNAs in PC pathogenesis and treatment resistance.

Keywords: LncRNA; Pancreatic cancer; Pathogenesis; Treatment resistance.

Publication types

Review

MeSH terms

Cell Differentiation
Gene Expression Regulation, Neoplastic / genetics
Humans
Pancreatic Neoplasms* / genetics
Pancreatic Neoplasms* / metabolism
Pancreatic Neoplasms* / therapy
Prognosis
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding