Incidence and Clinical Phenotype of Multisystem Inflammatory Syndrome in Children After Two SARS-CoV-2 Pandemic Waves: A Croatian Prospective Nationwide Study

Lorna Stemberger Marić; Vladimir Trkulja; Davor Petrović; Kristina Lah Tomulić; Ines Bartulović; Goran Tešović; CroMIS-C Study Group

doi:10.1097/INF.0000000000003924

Incidence and Clinical Phenotype of Multisystem Inflammatory Syndrome in Children After Two SARS-CoV-2 Pandemic Waves: A Croatian Prospective Nationwide Study

Pediatr Infect Dis J. 2023 Jul 1;42(7):e229-e231. doi: 10.1097/INF.0000000000003924. Epub 2023 Apr 4.

Authors

Lorna Stemberger Marić^{1

2}, Vladimir Trkulja³, Davor Petrović⁴, Kristina Lah Tomulić^{5

6}, Ines Bartulović⁷, Goran Tešović^{1

8}; CroMIS-C Study Group

Collaborators

CroMIS-C Study Group:
Sanja Delin, Sanja Dorner, Sanja Kurečić Filipović, Ana Fluksek, Hrvoje Kniewald, Srđan Roglić, Nina Krajcar, Joško Markić, Branka Polić, Aleksandar Ovuka, Saša Sršen

Affiliations

¹ From the University Hospital for Infectious Diseases "Dr. Fran Mihaljević," Zagreb, Croatia.
² Department for Infectious diseases, University of Zagreb, School of Medicine, Croatia.
³ Professor at Department of Pharmacology, University of Zagreb, School of Medicine.
⁴ Department of Pediatrics, University Hospital of Split, Croatia.
⁵ Department of Pediatrics, Rijeka University Hospital Center, Croatia.
⁶ Department of Pediatrics, Faculty of Medicine, University of Rijeka, Croatia.
⁷ Department of Pediatrics, University Hospital Osijek, Croatia.
⁸ Professor at Department for Infectious diseases, University of Zagreb, School of Medicine, Croatia.

Abstract

This prospective nationwide study in Croatia (March 1, 2020-December 31, 2021) embraced 121 children with multisystem inflammatory syndrome. Incidence rates, disease course and outcomes were similar to those reported from other European countries. The severe acute respiratory syndrome coronavirus 2 virus Alpha strain appeared associated with a higher propensity to result in multisystem inflammatory syndrome in children than the Delta strain but did not appear related to disease severity.

MeSH terms

COVID-19* / complications
COVID-19* / epidemiology
Croatia / epidemiology
Humans
Incidence
Pandemics
Prospective Studies
SARS-CoV-2*
Systemic Inflammatory Response Syndrome / complications
Systemic Inflammatory Response Syndrome / epidemiology

Supplementary concepts

pediatric multisystem inflammatory disease, COVID-19 related