Energizing Mitochondria to Prevent Mobility Loss in Aging: Rationale and Hypotheses

Qu Tian; Philip R Lee; Keenan A Walker; Luigi Ferrucci

doi:10.1249/JES.0000000000000315

Energizing Mitochondria to Prevent Mobility Loss in Aging: Rationale and Hypotheses

Exerc Sport Sci Rev. 2023 Jul 1;51(3):96-102. doi: 10.1249/JES.0000000000000315. Epub 2023 Apr 14.

Authors

Qu Tian¹, Philip R Lee¹, Keenan A Walker², Luigi Ferrucci¹

Affiliations

¹ Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, MD.
² Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD.

Abstract

Based on recent studies from our group and others, we hypothesize that mitochondrial dysfunction during aging may be the root cause of mobility decline through deficits in the musculoskeletal and central nervous systems. Mitochondrial dysfunction could be a therapeutic target to prevent mobility decline in aging.

Publication types

Research Support, N.I.H., Intramural

MeSH terms

Aging* / physiology
Humans
Mitochondria* / physiology

Grants and funding

Z99 AG999999/ImNIH/Intramural NIH HHS/United States