Is Bioactive Glass an Effective Agent in Pulp-capping Treatments?: A Randomized Controlled Clinical Trial with One-year Follow-up

J Contemp Dent Pract. 2022 Nov 1;23(11):1128-1135. doi: 10.5005/jp-journals-10024-3428.

Abstract

Aims: Indirect pulp-capping treatment is a procedure applied to teeth with deep and close-to-pulp caries lesions and without pulp degeneration symptoms. This study aimed to explore the use of a material containing bioactive glass for indirect pulp capping in primary and permanent teeth.

Materials and methods: The study included 145 patients, aged 4-15 years, without any systemic disease and 100 primary second molars and 100 permanent first molars in total. Four material groups were determined: calcium hydroxide (Dycal-DC group), glass ionomer (Biner LC-BC group), calcium silicate (TheraCal LC-TC group), and Bioactive glass-containing ACTIVA BioACTIVE-AC group. Clinical and radiographic evaluations were made 1, 3, 6, 9, and 12 months after the treatment. The data obtained were statistically analyzed using the Chi-square test.

Results: During the 12-month follow-up period, the DC and TC groups were more successful clinically (94%), while the DC and AC groups were found to be more successful radiographically (94%). However, no statistically significant difference was found between the groups (p > 0.05).

Conclusions: The results of this study supported the view that the success of indirect pulp-capping treatments was independent of the material used.

Clinical significance: This study demonstrated that a material containing bioactive glass, ACTIVA BioACTIVE-Base/Liner, can be used safely in indirect pulp-capping processes.

Keywords: Bioactive glasses; Biocompatible materials; Calcium hydroxide; Dental pulp Pulp capping agents..

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Calcium Compounds / therapeutic use
  • Calcium Hydroxide / therapeutic use
  • Dental Caries* / drug therapy
  • Dental Caries* / therapy
  • Dental Pulp / diagnostic imaging
  • Dental Pulp Capping / methods
  • Follow-Up Studies
  • Humans
  • Pulp Capping and Pulpectomy Agents* / therapeutic use
  • Silicates / therapeutic use

Substances

  • Calcium Compounds
  • Calcium Hydroxide
  • Silicates
  • Pulp Capping and Pulpectomy Agents