Insufficient evidence for non-neutrality of synonymous mutations
Nature
.
2023 Apr;616(7957):E8-E9.
doi: 10.1038/s41586-023-05865-4.
Epub 2023 Apr 19.
Authors
Leonid Kruglyak
1
2
3
,
Andreas Beyer
4
5
,
Joshua S Bloom
6
7
8
,
Jan Grossbach
4
5
,
Tami D Lieberman
9
10
,
Christopher P Mancuso
9
10
,
Matthew S Rich
11
,
Gavin Sherlock
12
,
Craig D Kaplan
13
Affiliations
1
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
[email protected]
.
2
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.
[email protected]
.
3
Howard Hughes Medical Institute, Chevy Chase, MD, USA.
[email protected]
.
4
Cluster of Excellence on Cellular Stress Responses in Age-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
5
Institute for Genetics, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany.
6
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
7
Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA, USA.
8
Howard Hughes Medical Institute, Chevy Chase, MD, USA.
9
Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
10
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
11
Department of Biology, University of Utah, Salt Lake City, UT, USA.
12
Department of Genetics, Stanford University, Stanford, CA, USA.
13
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
[email protected]
.
PMID:
37076734
PMCID:
PMC11343442
DOI:
10.1038/s41586-023-05865-4
No abstract available
Publication types
Letter
Comment
MeSH terms
Evidence Gaps
Mutation
Saccharomyces cerevisiae*
Selection, Genetic
Silent Mutation*
Grants and funding
HHMI/Howard Hughes Medical Institute/United States
R01 GM102308/GM/NIGMS NIH HHS/United States