Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova

Emerg Infect Dis. 2023 May;29(5):1046-1050. doi: 10.3201/eid2905.230035.

Abstract

Applying whole-genome-sequencing, we aimed to detect transmission events of multidrug-resistant/rifampin-resistant strains of Mycobacterium tuberculosis complex at a tuberculosis hospital in Chisinau, Moldova. We recorded ward, room, and bed information for each patient and monitored in-hospital transfers over 1 year. Detailed molecular and patient surveillance revealed only 2 nosocomial transmission events.

Keywords: Beijing; Moldova; TB; Ural; WGS; antimicrobial resistance; bacteria; multidrug-resistant tuberculosis; rifampin-resistant tuberculosis; tuberculosis and other mycobacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / pharmacology
  • Antitubercular Agents / therapeutic use
  • Cross Infection* / drug therapy
  • Cross Infection* / epidemiology
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Microbial Sensitivity Tests
  • Moldova / epidemiology
  • Mycobacterium tuberculosis* / genetics
  • Tuberculosis, Multidrug-Resistant* / diagnosis
  • Tuberculosis, Multidrug-Resistant* / drug therapy
  • Tuberculosis, Multidrug-Resistant* / epidemiology

Substances

  • Antitubercular Agents