A Systematic Review of the Granular Cell Odontogenic Fibroma and Report of a New Case

Background: Granular Cell Odontogenic Fibroma (GCOF) is a rare odontogenic neoplasm reported over time with different names. The purpose of this study is to review all available data on the GCOF in the scientific literature, with a summary of all reported cases and a report of a new case.

Methods: This review was conducted following the PRISMA guidelines. An electronic search was performed up to November 2022.

Results: Thirty-nine studies reporting fifty-three cases were included. GCOF is a rare neoplasm among the odontogenic tumors, with a higher prevalence in women of the middle-aged and white population. This lesion occurs mostly on the posterior region of the mandible. Furthermore, based on clinical, radiographic, and histopathologic features, conservative treatment was the most reported choice with recurrence reported in two cases.

Conclusion: GCOF remains controversial due to the still unsolved histogenesis.