Biobanks: The unmet need in heart failure management

Giovanna Manzi; Marco Valerio Mariani; Domenico Filomena; Roberto Poscia; Paolo Severino; Antonio Iaconelli; Tommaso Recchioni; Rosalinda Madonna; Carmine Dario Vizza; Roberto Badagliacca

doi:10.1016/j.vph.2023.107179

Biobanks: The unmet need in heart failure management

Vascul Pharmacol. 2023 Jun:150:107179. doi: 10.1016/j.vph.2023.107179. Epub 2023 Apr 28.

Affiliations

¹ Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, Rome 00161, Italy.
² Clinical Research Unit, AOU Policlinico Umberto I- Sapienza University of Rome, Viale del Policlinico, 155, Rome 00161, Italy.
³ Department of Cardiovascular and Thoracic Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
⁴ Cardiology Unit, Department of Surgical, Medical and Molecular Pathology and of Critical Sciences, University of Pisa - UNIPI, Pisa, Italy.
⁵ Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, 155, Rome 00161, Italy. Electronic address: [email protected].

PMID: 37121386
DOI: 10.1016/j.vph.2023.107179

Abstract

Heart failure (HF) represents a major health and economic issue, with increasing morbidity and mortality in spite of novel therapeutic weapons. The disappointing results of HF management may be due to the current therapeutic approach based on the paradigm "one fits all", that cannot apply to a complex and multifaceted syndrome as HF. At this regard, the European Union is developing policies to move from reductionism to precision medicine, in order to identify specific disease biomarkers and develop targeted therapeutic strategies. The institution of biobanks may represent the game changer in HF scenario, providing a collection of human biological materials with the related medical and epidemiological data fueling the development of personalized therapeutic approach and fostering current and/or future research projects.

Keywords: Biobanks; Heart failure; Precision medicine.

Publication types

Review

MeSH terms

Biological Specimen Banks*
Heart Failure* / diagnosis
Heart Failure* / therapy
Humans