Non-oral continuous drug delivery based therapies and sleep dysfunction in Parkinson's disease

J Neural Transm (Vienna). 2023 Nov;130(11):1443-1449. doi: 10.1007/s00702-023-02640-7. Epub 2023 May 1.

Abstract

Continuous drug delivery (CDD) has emerged as a feasible and pragmatic therapeutic option for dopamine replacement therapy in advanced Parkinson's disease (PD). CDD aims to mimic the physiological tonic dopamine release from striatal dopaminergic neurons and thus reduces the severity and duration of motor and non-motor fluctuations partly related to pulsatile levodopa stimulation. Non-motor symptoms and fluctuations are ubiquitous in PD and include sleep dysfunction, a problem that occurs in over 90% of PD patients across all stages, from prodromal to palliative. In this review, we discuss the currently available and in development non-oral dopaminergic CDD strategies with a focus on their efficacy in the treatment of the burdensome sleep dysfunction in PD.

Keywords: Apomorphine; Continous drug delivery; LCIG; LECIGON; Levodopa; Park-sleep; Parkinsons; Sleep.

Publication types

  • Review

MeSH terms

  • Antiparkinson Agents / therapeutic use
  • Dopamine
  • Humans
  • Levodopa
  • Parkinson Disease* / complications
  • Parkinson Disease* / drug therapy
  • Sleep
  • Sleep Wake Disorders* / drug therapy
  • Sleep Wake Disorders* / etiology

Substances

  • Antiparkinson Agents
  • Dopamine
  • Levodopa