Diabetes Mellitus Related Anterior Uveitis - An Overlooked Clinical Entity

Ocul Immunol Inflamm. 2024 Aug;32(6):1061-1064. doi: 10.1080/09273948.2023.2203204. Epub 2023 May 1.

Abstract

Background: This study aimed to evaluate the characteristics of anterior uveitis in patients presenting with poorly controlled diabetes mellitus and with no other identifiable cause for their uveitis.

Methods: A retrospective study of 121 eyes in 89 patients who presented at Auckland District Health Board with idiopathic acute anterior uveitis and uncontrolled diabetes between September 2009 and January 2022.

Results: The diagnosis of diabetes mellitus was known prior to presentation in 80 subjects (89.9%) and was discovered as a result of screening tests in the remainder. Mean HbA1c at presentation was 117.3 mmol/mol. Most uveitis was severe with 3+ (30 eyes, 25.4%) or 4+ cells (30 eyes, 25.4%) in the anterior chamber. Recurrence occurred in 22 eyes (18.2%) and was associated with elevated HbA1c. The visual prognosis was good with median visual acuity at 12 months of 6/7.5.

Conclusion: Poorly controlled diabetes can be associated with acute anterior uveitis.

Keywords: Anterior uveitis; diabetes mellitus; intraocular inflammation; iritis; uveitis.

MeSH terms

  • Acute Disease
  • Adult
  • Aged
  • Aged, 80 and over
  • Diabetes Mellitus / diagnosis
  • Female
  • Glycated Hemoglobin* / metabolism
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Uveitis, Anterior* / diagnosis
  • Uveitis, Anterior* / etiology
  • Visual Acuity* / physiology
  • Young Adult

Substances

  • Glycated Hemoglobin
  • hemoglobin A1c protein, human