Cold sensory transduction through the STIM-Orai signaling pathway

Yandong Zhou; Michelle R Jennette; Donald L Gill

doi:10.1016/j.ceca.2023.102735

Cold sensory transduction through the STIM-Orai signaling pathway

Cell Calcium. 2023 Jun:112:102735. doi: 10.1016/j.ceca.2023.102735. Epub 2023 Apr 21.

Authors

Yandong Zhou¹, Michelle R Jennette¹, Donald L Gill²

Affiliations

¹ Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, United States of America.
² Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, PA 17033, United States of America. Electronic address: [email protected].

PMID: 37126912
DOI: 10.1016/j.ceca.2023.102735

Abstract

The STIM-Orai signaling pathway mediates Ca²⁺ signals vital for controlling transcription and cell growth. The Ca²⁺ sensing STIM proteins are activated by depletion of Ca²⁺ stored in the ER, and translocate into ER-PM junctions to gate PM Orai channels. STIM1 activation also results from heating STIM1 proteins, and new evidence reveals the STIM1-mediated gating of Orai1 channels is activated by noxious cooling of cells. This activation of the STIM-Orai pathway may be important in mediating vascular dilation that occurs in response to severe cold exposure.

Keywords: Calcium signaling; Orai channels; STIM proteins.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Calcium / metabolism
Calcium Signaling* / physiology
ORAI1 Protein / metabolism
Signal Transduction*
Stromal Interaction Molecule 1 / metabolism

Substances

ORAI1 Protein
Stromal Interaction Molecule 1
Calcium

Grants and funding

R35 GM131916/GM/NIGMS NIH HHS/United States