DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling

Sara Mellid; Fernando García; Luis Javier Leandro-García; Alberto Díaz-Talavera; Ángel Mario Martínez-Montes; Eduardo Gil; Bruna Calsina; María Monteagudo; Rocío Letón; Juan María Roldán-Romero; María Santos; Javier Lanillos; Carlos Valdivia; Natalia Martínez-Puente; Javier de Nicolás-Hernández; Scherezade Jiménez; Manuel Pérez-Martínez; Emiliano Honrado; Javier Coloma; Ana Cerezo; Clara María Santiveri; Manel Esteller; Ramón Campos-Olivas; Eduardo Caleiras; Cristina Montero-Conde; Cristina Rodríguez-Antona; Javier Muñoz; Mercedes Robledo; Alberto Cascón

doi:10.1002/cac2.12427

DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling

Cancer Commun (Lond). 2023 Jul;43(7):838-843. doi: 10.1002/cac2.12427. Epub 2023 May 4.

Authors

Sara Mellid¹, Fernando García², Luis Javier Leandro-García¹, Alberto Díaz-Talavera^{1

3}, Ángel Mario Martínez-Montes¹, Eduardo Gil¹, Bruna Calsina¹, María Monteagudo¹, Rocío Letón¹, Juan María Roldán-Romero¹, María Santos¹, Javier Lanillos¹, Carlos Valdivia¹, Natalia Martínez-Puente^{1

3}, Javier de Nicolás-Hernández¹, Scherezade Jiménez⁴, Manuel Pérez-Martínez⁵, Emiliano Honrado⁶, Javier Coloma⁷, Ana Cerezo⁸, Clara María Santiveri⁹, Manel Esteller^{10

11

12

13}, Ramón Campos-Olivas⁹, Eduardo Caleiras¹⁴, Cristina Montero-Conde¹, Cristina Rodríguez-Antona¹, Javier Muñoz^{2

15

16}, Mercedes Robledo^{1

3}, Alberto Cascón^{1

3}

Affiliations

¹ Hereditary Endocrine Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
² Proteomics Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
³ Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain.
⁴ Monoclonal Antibodies Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
⁵ Confocal Microscopy Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
⁶ Anatomical Pathology Service, Hospital of León, León, Castilla y León, Spain.
⁷ Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
⁸ CNIO-Lilly Cell Signalling and Immunometabolism Section, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
⁹ Spectroscopy and Nuclear Magnetic Resonance Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
¹⁰ Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Spain.
¹¹ Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
¹² Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
¹³ Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), L'Hospitalet, Barcelona, Spain.
¹⁴ Histopathology Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
¹⁵ Cell Signaling and Clinical Proteomics Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain.
¹⁶ Ikerbasque, Basque Foundation for Science, Bilbao, Spain.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adrenal Gland Neoplasms* / genetics
Humans
Mutation
Paraganglioma* / genetics
Pheochromocytoma* / genetics
Proteome / genetics

Substances

Proteome