Noninvasive Brain Stimulation Techniques for Treatment-Resistant Depression: Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation

Andrea Boscutti; Juliana Mendonca De Figueiredo; Dana Razouq; Nicholas Murphy; Raymond Cho; Sudhakar Selvaraj

doi:10.1016/j.psc.2023.02.005

Noninvasive Brain Stimulation Techniques for Treatment-Resistant Depression: Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation

Psychiatr Clin North Am. 2023 Jun;46(2):307-329. doi: 10.1016/j.psc.2023.02.005. Epub 2023 Mar 15.

Authors

Andrea Boscutti¹, Juliana Mendonca De Figueiredo², Dana Razouq², Nicholas Murphy³, Raymond Cho³, Sudhakar Selvaraj⁴

Affiliations

¹ Louis. A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
² Louis. A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
³ Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, Houston, TX, USA; The Menninger Clinic, Houston, TX, USA.
⁴ Louis. A. Faillace, MD, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: [email protected].

PMID: 37149347
DOI: 10.1016/j.psc.2023.02.005

Abstract

Transcranial magnetic stimulation is a safe, effective, and well-tolerated intervention for depression; it is currently approved for treatment-resistant depression. This article summarizes the mechanism of action, evidence of clinical efficacy, and the clinical aspects of this intervention, including patient evaluation, stimulation parameters selection, and safety considerations. Transcranial direct current stimulation is another neuromodulation treatment for depression; although promising, the technique is not currently approved for clinical use in the United States. The final section outlines the open challenges and future directions of the field.

Keywords: Neuromodulation; Neuroplasticity; Noninvasive brain stimulation; TMS; Transcranial direct current stimulation; Transcranial magnetic stimulation; Treatment-resistant depression; tDCS.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Brain / physiology
Depression
Humans
Transcranial Direct Current Stimulation* / methods
Transcranial Magnetic Stimulation* / methods
Treatment Outcome

Abstract

Publication types

MeSH terms

Grants and funding