CD19 chimeric antigen receptor T-cell therapy in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia without complete molecular response at 3 months

Zhenzhen Yao; Bin Gu; Jia Chen; Yang Xu; Feng Chen; Shengli Xue; Huiying Qiu; Xiaowen Tang; Yue Han; Suning Chen; Aining Sun; Lei Yu; Yanming Zhang; Depei Wu; Ying Wang

doi:10.1038/s41408-023-00848-0

CD19 chimeric antigen receptor T-cell therapy in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia without complete molecular response at 3 months

Blood Cancer J. 2023 May 10;13(1):75. doi: 10.1038/s41408-023-00848-0.

Authors

Zhenzhen Yao^#¹, Bin Gu^#¹, Jia Chen^{1

2}, Yang Xu^{1

2

3}, Feng Chen¹, Shengli Xue^{1

2}, Huiying Qiu^{1

2}, Xiaowen Tang^{1

2

3}, Yue Han^{1

2

3}, Suning Chen^{1

2

3}, Aining Sun^{1

2}, Lei Yu⁴, Yanming Zhang⁵, Depei Wu^{6

7

8

9}, Ying Wang^{10

11

12}

Affiliations

¹ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China.
² Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China.
³ Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China.
⁴ Shanghai Unicar-Therapy Bio-medicine Technology Co., Ltd, Shanghai, China.
⁵ Department of Hematology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, China. [email protected].
⁶ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. [email protected].
⁷ Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. [email protected].
⁸ Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China. [email protected].
⁹ State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China. [email protected].
¹⁰ National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. [email protected].
¹¹ Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, China. [email protected].
¹² Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Suzhou, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antigens, CD19
Cell- and Tissue-Based Therapy
Humans
Immunotherapy, Adoptive
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / therapy
Receptors, Chimeric Antigen* / genetics

Substances

Receptors, Chimeric Antigen
Antigens, CD19