This study followed up the immune memory after 3-dose revaccination among infants with non-and low-response following primary hepatitis B (HepB) vaccination. About 120 children without self-booster doses were finally included who had anti-HBs<10 mIU/ml (anti-HBs negative) at the time of follow-up, of whom 86 children completed blood sampling and anti-HBs testing. Before the challenge dose, all 86 children were negative for anti-HBs, and the GMC of anti-HBs was<10 mIU/ml. The seropositive conversion rate of anti-HBs was 100% and the GMC of anti-HBs was 886.11 (95%CI: 678.15-1 157.84) mIU/ml after the challenge dose. Compared with those with GMC<7 mIU/ml before the challenge dose, infants with GMC>7 mIU/ml had a higher anti-HBs level after the challenge dose. The β value (95%CI) was 0.82 (0.18-1.46) (P=0.012). Compared with those with GMC<1 000 mIU/ml at primary vaccination, infants with GMC≥1 000 mIU/ml had a higher anti-HBs level after the challenge dose. The β value (95%CI) was 0.78 (0.18-1.38)(P=0.012). The results showed a stronger immune memory was found at 9 years after revaccination among infants with non-and low-response to HepB.
本研究对乙型肝炎疫苗（HepB）初次免疫低/无应答婴儿再次免疫后的免疫记忆进行了随访观察，最终将随访时抗-HBs<10 mIU/ml（抗-HBs阴性）且未进行自行加强免疫的120名儿童纳入研究，其中有86名儿童完成采血和抗-HBs检测。接种激发剂次前，86名儿童抗-HBs全部阴性，抗-HBs的GMC均<10 mIU/ml；激发剂次接种后，抗-HBs阳转率为100%，抗-HBs的GMC为886.11（95%CI：678.15~1 157.84）mIU/ml。与接种激发剂次前抗-HBs<4 mIU/ml者相比，抗-HBs>7 mIU/ml者接种激发剂次后的抗-HBs水平较高，β（95%CI）值为0.82（0.18~1.46）（P=0.012）；与初次免疫后抗-HBs<1 000 mIU/ml者相比，初次免疫后抗-HBs≥1 000 mIU/ml者接种激发剂次后的抗-HBs水平较高，β（95%CI）值为0.78（0.18~1.38）（P=0.012）。结果提示，HepB初次免疫低/无应答婴儿再次免疫9年后仍存在较强免疫记忆。.