Absorption of fortification iron from milk formulas in infants

Am J Clin Nutr. 1986 Jun;43(6):917-22. doi: 10.1093/ajcn/43.6.917.

Abstract

The bioavailability of iron added to different types of cows' milk formulas was studied using mono-isotopic and double-isotopic methods in 396 infants aged 5-18 mo. All the milk formulas were fortified with ferrous sulfate in concentrations varying between 10 and 19 mg elemental iron/liter. Iron absorption from low-fat milks and full-fat milks varied from 2.9 to 5.1%. A higher range of mean absorption, 5.9 to 11.3%, was observed in the same formulas with the addition of ascorbic acid at concentrations of 100 mg/l or higher (up to 800 mg/l), demonstrating its enhancing effect on iron absorption in fortified milks. The amount of milk fat, the addition of carbohydrates, or acidification did not seem to influence iron absorption.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ascorbic Acid / metabolism
  • Cattle
  • Chile
  • Dairy Products
  • Female
  • Hemoglobins / analysis
  • Humans
  • Infant
  • Infant Food*
  • Infant Nutritional Physiological Phenomena*
  • Intestinal Absorption
  • Iron / metabolism*
  • Male
  • Milk*
  • Nutritive Value
  • Scintillation Counting
  • Transferrin / analysis

Substances

  • Hemoglobins
  • Transferrin
  • Iron
  • Ascorbic Acid