Platelets and their derived extracellular vesicles: The new generation of markers in non-small cell lung cancer management

Roberta Tasso; Silvia Marconi; Giovanni Rossi; Carlo Genova; Simona Coco

doi:10.1016/j.drudis.2023.103616

Platelets and their derived extracellular vesicles: The new generation of markers in non-small cell lung cancer management

Drug Discov Today. 2023 Jul;28(7):103616. doi: 10.1016/j.drudis.2023.103616. Epub 2023 May 18.

Authors

Roberta Tasso¹, Silvia Marconi², Giovanni Rossi³, Carlo Genova⁴, Simona Coco⁵

Affiliations

¹ Dipartimento di Medicina Sperimentale (DIMES); Università degli Studi di Genova, Genova, Italy; UO Oncologia Cellulare, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
² Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy. Electronic address: [email protected].
³ UOC Oncologia Medica 2, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
⁴ UOC Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy; Dipartimento di Medicina Interna e Specialità Mediche (DiMI); Università degli Studi di Genova, Genova, Italy.
⁵ Lung Cancer Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

PMID: 37196761
DOI: 10.1016/j.drudis.2023.103616

Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death. Circulating elements have gained significant interest in the diagnosis and prognosis of NSCLC patients. Among these, platelets (PLTs) and their derived extracellular vesicles (P-EVs) are emerging eligible biosources both in terms of number and carriers of genetic materials (RNA, proteins, and lipids). PLTs are mainly produced by the shedding of megakaryocytes and together with P-EVs, participate in a variety of pathological processes including thrombosis, tumor progression, and metastasis. Here, we performed an extensive literature review focusing on PLTs and P-EVs as potential diagnostic, prognostic, and predictive markers for NSCLC patient management.

Keywords: extracellular vesicles; non-small cell lung cancer; platelets; predictive marker; prognosis; tumor-educated platelets.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Blood Platelets / metabolism
Blood Platelets / pathology
Carcinoma, Non-Small-Cell Lung* / drug therapy
Carcinoma, Non-Small-Cell Lung* / metabolism
Extracellular Vesicles* / metabolism
Humans
Lung Neoplasms* / metabolism
Prognosis