Accelerated intermittent theta burst stimulation for major depressive disorder or bipolar depression: A systematic review and meta-analysis

Asian J Psychiatr. 2023 Jul:85:103618. doi: 10.1016/j.ajp.2023.103618. Epub 2023 May 6.

Abstract

We aimed to systematically evaluate the clinical efficacy and safety of accelerated intermittent theta burst stimulation (aiTBS) for patients with major depressive disorder (MDD) or bipolar depression (BD). A random-effects model was adopted to analyze the primary and secondary outcomes using the Review Manager, Version 5.3 software. This meta-analysis (MA) identified five double-blind randomized controlled trials (RCTs) comprising 239 MDD or BD patients with a major depressive episode. Active aiTBS overperformed sham stimulation in the study-defined response. This MA found preliminary evidence that active aiTBS resulted in a greater response in treating major depressive episodes in MDD or BD patients than sham stimulation.

Keywords: Accelerated theta burst stimulation; Depression; Meta-analysis; Remission; Response.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Bipolar Disorder* / therapy
  • Depressive Disorder, Major* / therapy
  • Double-Blind Method
  • Humans
  • Randomized Controlled Trials as Topic
  • Transcranial Magnetic Stimulation / methods
  • Treatment Outcome