Role of neutrophils on cancer cells and other immune cells in the tumor microenvironment

Junpei Zhong; Siwen Zong; Jiayang Wang; Mingrui Feng; Jie Wang; Hongyan Zhang; Lixia Xiong

doi:10.1016/j.bbamcr.2023.119493

Role of neutrophils on cancer cells and other immune cells in the tumor microenvironment

Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119493. doi: 10.1016/j.bbamcr.2023.119493. Epub 2023 May 17.

Authors

Junpei Zhong¹, Siwen Zong², Jiayang Wang³, Mingrui Feng², Jie Wang⁴, Hongyan Zhang⁵, Lixia Xiong⁶

Affiliations

¹ Department of Pathophysiology, Medical College, Nanchang University, Nanchang 330006, China.
² Second Clinical Medical College, Nanchang University, Nanchang 330006, China.
³ First Clinical Medical College, Nanchang University, Nanchang 330006, China.
⁴ Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian province university, Xiamen 361023, China.
⁵ Department of Burn, The First Affiliated Hospital, Nanchang University, Nanchang 330066, China. Electronic address: [email protected].
⁶ Department of Pathophysiology, Medical College, Nanchang University, Nanchang 330006, China; Key Laboratory of Functional and Clinical Translational Medicine, Xiamen Medical College, Fujian province university, Xiamen 361023, China. Electronic address: [email protected].

PMID: 37201766
DOI: 10.1016/j.bbamcr.2023.119493

Abstract

The notion that neutrophils only perform a specific set of single functions in the body has changed with the advancement of research methods. As the most abundant myeloid cells in human blood, neutrophils are currently emerging as important regulators of cancer. Given the duality of neutrophils, neutrophil-based tumor therapy has been clinically carried out in recent years and has made some progress. But due to the complexity of the tumor microenvironment, the therapeutic effect is still not satisfactory. Therefore, in this review, we discuss the direct interaction of neutrophils with the five most common cancer cells and other immune cells in the tumor microenvironment. Also, this review covered current limitations, potential future possibilities, and therapeutic approaches targeting neutrophil function in cancer therapy.

Keywords: Immune cells; Neutrophils; TAN; Therapy strategy; cancer cells; cancer development.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Myeloid Cells
Neoplasms* / pathology
Neutrophils*
Tumor Microenvironment