Longitudinal changes in metabolic network activity in early Alzheimer's disease

Alzheimers Dement. 2023 Sep;19(9):4061-4072. doi: 10.1002/alz.13137. Epub 2023 May 19.

Abstract

Introduction: The progression of Alzheimer's disease (AD) has been linked to two metabolic networks, the AD-related pattern (ADRP) and the default mode network (DMN).

Methods: Converting and clinically stable cognitively normal subjects (n = 47) and individuals with mild cognitive impairment (n = 96) underwent 2-[18 F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) three or more times over 6 years (nscans = 705). Expression levels for ADRP and DMN were measured in each subject and time point, and the resulting changes were correlated with cognitive performance. The role of network expression in predicting conversion to dementia was also evaluated.

Results: Longitudinal increases in ADRP expression were observed in converters, while age-related DMN loss was seen in converters and nonconverters. Cognitive decline correlated with increases in ADRP and declines in DMN, but conversion to dementia was predicted only by baseline ADRP levels.

Discussion: The results point to the potential utility of ADRP as an imaging biomarker of AD progression.

Keywords: Alzheimer's disease-related pattern; FDG PET; conversion; default mode network; mild cognitive impairment.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Alzheimer Disease* / diagnostic imaging
  • Alzheimer Disease* / metabolism
  • Brain / diagnostic imaging
  • Brain / metabolism
  • Cognitive Dysfunction* / diagnostic imaging
  • Cognitive Dysfunction* / metabolism
  • Disease Progression
  • Fluorodeoxyglucose F18 / metabolism
  • Humans
  • Positron-Emission Tomography / methods

Substances

  • Fluorodeoxyglucose F18