Vaccine development for mosquito-borne viral diseases

Zhiwei Huang; Yuxuan Zhang; Hongyu Li; Jiajie Zhu; Wanchen Song; Keda Chen; Yanjun Zhang; Yongliang Lou

doi:10.3389/fimmu.2023.1161149

Vaccine development for mosquito-borne viral diseases

Front Immunol. 2023 May 12:14:1161149. doi: 10.3389/fimmu.2023.1161149. eCollection 2023.

Authors

Zhiwei Huang¹, Yuxuan Zhang², Hongyu Li², Jiajie Zhu², Wanchen Song³, Keda Chen², Yanjun Zhang⁴, Yongliang Lou¹

Affiliations

¹ School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China.
² Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
³ School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.
⁴ Department of Microbiology, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.

Abstract

Mosquito-borne viral diseases are a group of viral illnesses that are predominantly transmitted by mosquitoes, including viruses from the Togaviridae and Flaviviridae families. In recent years, outbreaks caused by Dengue and Zika viruses from the Flaviviridae family, and Chikungunya virus from the Togaviridae family, have raised significant concerns for public health. However, there are currently no safe and effective vaccines available for these viruses, except for CYD-TDV, which has been licensed for Dengue virus. Efforts to control the transmission of COVID-19, such as home quarantine and travel restrictions, have somewhat limited the spread of mosquito-borne viral diseases. Several vaccine platforms, including inactivated vaccines, viral-vector vaccines, live attenuated vaccines, protein vaccines, and nucleic acid vaccines, are being developed to combat these viruses. This review analyzes the various vaccine platforms against Dengue, Zika, and Chikungunya viruses and provides valuable insights for responding to potential outbreaks.

Keywords: Chikungunya virus; Zika virus; dengue virus; mosquito-borne viral disease; vaccine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
COVID-19*
Chikungunya virus*
Culicidae*
Dengue* / epidemiology
Dengue* / prevention & control
Humans
Mosquito Vectors
Vaccine Development
Vaccines, Attenuated
Viral Vaccines*
Zika Virus Infection* / epidemiology
Zika Virus Infection* / prevention & control
Zika Virus*

Substances

Viral Vaccines
Vaccines, Attenuated

Grants and funding

This work was supported by the Key Research and Development Program of Zhejiang Province (2021C03044), Major horizontal project of Zhejiang Shuren University (2021D1034), 2022 High-level Pre-research of Zhejiang Shuren University (ZSJ17722302C) and the National Natural Science Foundation of China (Grant No. 32000293) and Guangxi Natural Science Foundation (Grant No. 2020JJA130077).