Divergent Synthesis of Tetrasubstituted Phenols via [3 + 3] Cycloaddition Reaction of Vinyl Sulfoxonnium Ylides with Cyclopropenones

Org Lett. 2023 Jun 16;25(23):4286-4291. doi: 10.1021/acs.orglett.3c01327. Epub 2023 Jun 2.

Abstract

Two categories of tetrasubstituted phenols were prepared via the cycloaddition reaction of vinyl sulfoxonnium ylides with cyclopropenones in a switchable manner. Copper carbenoid was proposed as the active intermediate in the process of 2,3,4,5-tetrasubstituted phenols formation, while 2,3,5,6-tetrasubstituted phenols were generated via the direct [3 + 3] annulation of vinyl sulfoxonnium ylides with cyclopropenones under metal-free conditions. Further synthetic applications were also demonstrated.

MeSH terms

  • Catalysis
  • Copper*
  • Cycloaddition Reaction
  • Metals*

Substances

  • Copper
  • cyclopropenone
  • Metals
  • copper carbenoid