1 From the Division of Anaesthesiology, Intensive Care and Emergency Medicine, Department of Anaesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands (WB), Division of Anaesthesia, Analgesia, and Intensive Care, Department of Medicine and Surgery, University of Perugia, Italy (EDR) and Department of Paediatric Anaesthesia and Critical Care. La Paz University Children's Hospital, Madrid, IdiPaz Research Institute, Madrid, Spain (PG-P).