Utility of Urine Cultures During Febrile Neutropenia Workup in Hematopoietic Stem Cell Transplantation Recipients Without Urinary Symptoms

Mya Tran; Shannon Palmer; Dominic T Moore; Luther Bartelt; Anne Friedland; Tatjana Grgic; Anne Lachiewicz; Jon Ptachcinski; Arlene Sena; Morgan Trepte; David van Duin; Tessa M Andermann; Ryan Shaw

doi:10.1093/ofid/ofad236

Utility of Urine Cultures During Febrile Neutropenia Workup in Hematopoietic Stem Cell Transplantation Recipients Without Urinary Symptoms

Open Forum Infect Dis. 2023 May 3;10(5):ofad236. doi: 10.1093/ofid/ofad236. eCollection 2023 May.

Authors

Affiliations

¹ Department of Pharmacy, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA.
² Department of Pharmacy, Oregon Health and Sciences University, Portland, Oregon, USA.
³ Department of Biostatistics, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA.
⁴ Division of Infectious Diseases, Department of Medicine, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.
⁵ Department of Medicine, University of North Carolina Medical Center, Chapel Hill, North Carolina, USA.

Abstract

The utility of obtaining screening urine cultures for febrile neutropenia (FN) during hematopoietic stem cell transplant (HCT) is unknown. In 667 adult HCT patients with FN, only 40 (6%) were found with bacteriuria. Antibiotics were modified in 3 patients (0.4%) based on urine cultures and none developed urinary-associated infectious complications.

Keywords: blood and marrow transplant; febrile neutropenia; hematopoietic stem cell transplantation; urinary tract infection; urine culture.

Grants and funding

K23 AI163365/AI/NIAID NIH HHS/United States