Discovering the nuclear localization signal of Werner Helicase Interacting Protein 1

Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119502. doi: 10.1016/j.bbamcr.2023.119502. Epub 2023 Jun 1.

Abstract

Our study maps the classic nuclear localization signal (cNLS) domain within WRNIP that directs the protein's nuclear positioning.

Keywords: Importin; Maintenance genome stability; Monopartite; NLS; Nuclear transport; Werner.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Nuclear Localization Signals* / chemistry
  • Nuclear Localization Signals* / metabolism

Substances

  • Nuclear Localization Signals
  • WRNIP1 protein, human