Drug reaction eosinophilia and systemic symptoms: Clinical phenotypic patterns according to causative drug

Kimberly G Blumenthal; Santiago Alvarez-Arango; Daniela Kroshinsky; Ying-Chih Lo; Upeka Samarakoon; Abigail Rose Salem; Xiaoqing Fu; Fatima Bassir; Liqin Wang; Jordon Jaggers; Elizabeth Phillips; Li Zhou

doi:10.1016/j.jaad.2023.05.067

Drug reaction eosinophilia and systemic symptoms: Clinical phenotypic patterns according to causative drug

J Am Acad Dermatol. 2024 Jun;90(6):1240-1242. doi: 10.1016/j.jaad.2023.05.067. Epub 2023 Jun 3.

Authors

Affiliations

¹ Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts. Electronic address: [email protected].
² Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
³ Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts.
⁴ Harvard Medical School, Boston, Massachusetts; Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
⁵ Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts; Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts.
⁶ Division of General Internal Medicine and Primary Care, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
⁷ Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.
⁸ Department of Medicine, Center for Drug Safety and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia.

PMID: 37276931
PMCID: PMC11285528 (available on 2025-06-01)
DOI: 10.1016/j.jaad.2023.05.067

No abstract available

Keywords: DIHS; DRESS; SCAR; beta-lactam; drug reaction with eosinophilia and systemic symptoms; drug-induced hypersensitivity syndrome; epidemiology; pharmacoepidemiology; severe cutaneous adverse reaction; vancomycin.

Publication types

Letter

MeSH terms

Adult
Aged
Drug Hypersensitivity Syndrome* / diagnosis
Drug Hypersensitivity Syndrome* / etiology
Eosinophilia / chemically induced
Eosinophilia / diagnosis
Female
Humans
Male
Middle Aged
Phenotype*

Publication types

MeSH terms

Grants and funding