The Role of Membrane Lipids in the Formation and Function of Caveolae

Anne K Kenworthy; Bing Han; Nicholas Ariotti; Robert G Parton

doi:10.1101/cshperspect.a041413

The Role of Membrane Lipids in the Formation and Function of Caveolae

Cold Spring Harb Perspect Biol. 2023 Sep 1;15(9):a041413. doi: 10.1101/cshperspect.a041413.

Authors

Anne K Kenworthy^{1

2}, Bing Han^{3

2}, Nicholas Ariotti⁴, Robert G Parton^{5

6}

Affiliations

¹ Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, Virginia 22903, USA [email protected] [email protected].
² Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22903, USA.
³ Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, Virginia 22903, USA.
⁴ Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia.
⁵ Institute for Molecular Bioscience, The University of Queensland, 4072 Brisbane, Australia [email protected] [email protected].
⁶ Centre for Microscopy and Microanalysis, The University of Queensland, 4072 Brisbane, Australia.

Abstract

Caveolae are plasma membrane invaginations with a distinct lipid composition. Membrane lipids cooperate with the structural components of caveolae to generate a metastable surface domain. Recent studies have provided insights into the structure of essential caveolar components and how lipids are crucial for the formation, dynamics, and disassembly of caveolae. They also suggest new models for how caveolins, major structural components of caveolae, insert into membranes and interact with lipids.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Caveolae* / chemistry
Caveolae* / metabolism
Caveolins / analysis
Caveolins / metabolism
Endocytosis
Membrane Lipids* / analysis
Membrane Lipids* / metabolism

Substances

Membrane Lipids
Caveolins

Grants and funding

R01 HL144131/HL/NHLBI NIH HHS/United States