The role of Raptor in lymphocytes differentiation and function

Jianing Tang; Lu Yang; Fei Guan; Heather Miller; Niels Olsen Saraiva Camara; Louisa K James; Kamel Benlagha; Masato Kubo; Steffen Heegaard; Pamela Lee; Jiahui Lei; Hu Zeng; Chengwei He; Zhimin Zhai; Chaohong Liu

doi:10.3389/fimmu.2023.1146628

The role of Raptor in lymphocytes differentiation and function

Front Immunol. 2023 May 22:14:1146628. doi: 10.3389/fimmu.2023.1146628. eCollection 2023.

Authors

Jianing Tang¹, Lu Yang¹, Fei Guan¹, Heather Miller², Niels Olsen Saraiva Camara³, Louisa K James⁴, Kamel Benlagha⁵, Masato Kubo⁶, Steffen Heegaard^{7

8}, Pamela Lee⁹, Jiahui Lei¹, Hu Zeng^{10

11}, Chengwei He¹², Zhimin Zhai¹³, Chaohong Liu¹

Affiliations

¹ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China.
² Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States.
³ Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil.
⁴ Centre for Immunobiology, Bizard Institute, Queen Mary University of London, London, United Kingdom.
⁵ Université de Paris, Institut de Recherche Saint-Louis, EMiLy, Paris, France.
⁶ Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), Rikagaku Kenkyusho, Institute of Physical and Chemical Research (RIKEN) Yokohama Institute, Yokohama, Japan.
⁷ Department of Ophthalmology, Rigshospitalet Glostrup, Copenhagen, Denmark.
⁸ Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
⁹ Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China.
¹⁰ Department of Immunology, Mayo Clinic, Rochester, MN, United States.
¹¹ Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, United States.
¹² State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, China.
¹³ Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, China.

Abstract

Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.

Keywords: B cell; Raptor; T cell; immune; mTORC1.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cytokines* / metabolism
Mechanistic Target of Rapamycin Complex 1 / metabolism
Regulatory-Associated Protein of mTOR / genetics
Signal Transduction*

Substances

Regulatory-Associated Protein of mTOR
Mechanistic Target of Rapamycin Complex 1
Cytokines

Grants and funding

This project was supported by the Medjaden Academy & Research Foundation for Young Scientists (MJR20221030, MJR20221009).