Artificial reductant enhancement of the Lowry method for protein determination

Anal Biochem. 1986 Jun;155(2):243-8. doi: 10.1016/0003-2697(86)90432-x.

Abstract

Addition of dithiothreitol in the Lowry procedure 3 min after adding the Folin-Ciocalteau reagent produces immediate color development, with 35 to 60% greater absorbance per mass of protein used.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Colorimetry
  • Dithiothreitol
  • Indicators and Reagents
  • Molybdenum
  • Oxidation-Reduction
  • Proteins / analysis*
  • Spectrophotometry
  • Tungsten
  • Tungsten Compounds*

Substances

  • Folin's phenol reagent
  • Indicators and Reagents
  • Proteins
  • Tungsten Compounds
  • Molybdenum
  • Dithiothreitol
  • Tungsten