Severity outcomes associated with SARS-CoV-2 XBB variants, an observational analysis

Eili Y Klein; Amary Fall; Julie M Norton; Raghda E Eldesouki; Omar Abdullah; Lijie Han; Madeline Yunker; Heba H Mostafa

doi:10.1016/j.jcv.2023.105500

Severity outcomes associated with SARS-CoV-2 XBB variants, an observational analysis

J Clin Virol. 2023 Aug:165:105500. doi: 10.1016/j.jcv.2023.105500. Epub 2023 Jun 1.

Authors

Eili Y Klein¹, Amary Fall², Julie M Norton², Raghda E Eldesouki², Omar Abdullah², Lijie Han², Madeline Yunker², Heba H Mostafa²

Affiliations

¹ Department of Emergency Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, USA; One Health Trust, Washington, DC, USA. Electronic address: [email protected].
² Department of Pathology, Division of Medical Microbiology, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Abstract

The rapidity with which SARS-CoV-2 XBB variants rose to predominance has been alarming. We used a large cohort of patients diagnosed with Omicron infections between September 2022 and mid-February 2023 to evaluate the likelihood of admission or need for supplemental oxygen in patients infected with XBB variants. Our data showed no significant association between XBB or XBB.1.5 infections and admissions. Older age groups, lack of vaccination, immunosuppression and underlying heart, kidney, and lung disease showed significant associations with hospitalization.

Keywords: Admission; COVID-19; Omicron; XBB; XBB.1.5.

Publication types

Observational Study
Research Support, U.S. Gov't, P.H.S.
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Aged
COVID-19*
Cluster Analysis
Hospitalization
Humans
SARS-CoV-2 / genetics

Supplementary concepts

SARS-CoV-2 variants

Abstract

Publication types

MeSH terms

Supplementary concepts

Grants and funding