Remyelination by preexisting oligodendrocytes: Glass half full or half empty?

Sonia Nocera; Jonah R Chan

doi:10.1016/j.neuron.2023.05.001

Remyelination by preexisting oligodendrocytes: Glass half full or half empty?

Neuron. 2023 Jun 7;111(11):1689-1691. doi: 10.1016/j.neuron.2023.05.001.

Authors

Sonia Nocera¹, Jonah R Chan²

Affiliations

¹ Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, CA, USA. Electronic address: [email protected].
² Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, CA, USA. Electronic address: [email protected].

PMID: 37290399
DOI: 10.1016/j.neuron.2023.05.001

Abstract

The central dogma in remyelination states that the primary cellular source for myelin repair are the oligodendrocyte precursor cells. In this issue of Neuron, Mezydlo et al.¹ highlight the potential of preexisting oligodendrocytes as an alternative, albeit minor, source for new myelin, with implications for demyelinating disorder research and therapies.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cell Differentiation
Myelin Sheath / physiology
Neurons
Oligodendrocyte Precursor Cells* / physiology
Oligodendroglia / physiology
Remyelination*

Abstract

Publication types

MeSH terms

Grants and funding