TLR7/8 activation induces autoimmune vasculopathy and causes severe pulmonary arterial hypertension

Eur Respir J. 2023 Jul 20;62(1):2300204. doi: 10.1183/13993003.00204-2023. Print 2023 Jul.

Abstract

This study introduced a combination of autoimmune stimuli (TLR-7/8 agonist) and endothelial injury (Sugen) and established a novel rat model representing immune–vascular pathological events mimicking human PAH associated with autoimmune disorders https://bit.ly/3P3H5V0

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Familial Primary Pulmonary Hypertension
  • Humans
  • Hypertension, Pulmonary* / etiology
  • Pulmonary Arterial Hypertension* / complications
  • Toll-Like Receptor 7
  • Vascular Diseases* / complications

Substances

  • Toll-Like Receptor 7
  • TLR7 protein, human