Pigmented Epidermotropic Breast Carcinoma: A Diagnostic Pitfall Mimicking Melanoma A Case Report and Literature Review

Int J Surg Pathol. 2024 Apr;32(2):386-393. doi: 10.1177/10668969231177702. Epub 2023 Jun 8.

Abstract

We report the clinical and pathologic features of a patient with breast carcinoma, who developed clinically visible pigmented skin lesions during the course of the disease. The combination of clinical pigmentation, histological pagetoid epidermal spread, and considerable melanin pigment within tumour cells lead to a misdiagnosis of melanoma. This case provides a striking example of the ability of epidermotropic breast carcinoma to mimic melanoma. A literature review is also reported.

Keywords: cutaneous metastatic disease; epidermotropic carcinoma; melanoma.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Breast Neoplasms* / diagnosis
  • Epidermis
  • Female
  • Humans
  • Melanoma* / diagnosis
  • Pigmentation