Alkylation of N H-sulfoximines under Mitsunobu-type conditions

Org Biomol Chem. 2023 Jun 28;21(25):5181-5184. doi: 10.1039/d3ob00810j.

Abstract

Previously described approaches for the alkylation of NH-sulfoximines typically rely either on transition metal catalysis, or the use of traditional alkylation reagents and strong bases. Herein, we report a straightforward alkylation of diverse NH-sulfoximines under simple Mitsunobu-type conditions, despite the unusually high pKa of the NH center.