Gastroenteritis is Less Severe But is More Often Associated With Systemic Inflammation in SARS-CoV-2-positive Than in SARS-CoV-2-Negative Children

Gregorio P Milani; Danilo Buonsenso; Paola Marchisio; Carlo Agostoni; Chiara Maria Corso; Alfredo Guarino; Marco Poeta; Francesco Proli; Alessandra Drosi; Rosa Morello; Andrea Lo Vecchio

doi:10.1097/INF.0000000000004001

Gastroenteritis is Less Severe But is More Often Associated With Systemic Inflammation in SARS-CoV-2-positive Than in SARS-CoV-2-Negative Children

Pediatr Infect Dis J. 2023 Sep 1;42(9):e320-e322. doi: 10.1097/INF.0000000000004001. Epub 2023 Jun 14.

Authors

Gregorio P Milani^{1

2}, Danilo Buonsenso^{3

4}, Paola Marchisio^{1

2}, Carlo Agostoni^{1

2}, Chiara Maria Corso^{1

2}, Alfredo Guarino⁵, Marco Poeta⁵, Francesco Proli³, Alessandra Drosi³, Rosa Morello³, Andrea Lo Vecchio⁵

Affiliations

¹ From the Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
² Department of Clinical Sciences and Community Health, Università Degli Studi di Milano, Milan, Italy.
³ Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
⁴ Istituto di Igiene, Global Health Research Institute, Università Cattolica del Sacro Cuore, Rome, Italy.
⁵ Department of Translational Medical Sciences, Section of Pediatrics. University of Naples Federico II, Naples, Italy.

Abstract

This study aims to characterize the clinical and metabolic features of acute gastroenteritis in children with and without severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A multicenter case-control study was conducted in 2022 including 200 children. Clinical data and laboratory tests were analyzed. Children with SARS-CoV-2 presented less frequently hyponatremia and metabolic acidosis, but more often systemic inflammation as compared with children without SARS-CoV-2.

Publication types

Multicenter Study

MeSH terms

COVID-19* / complications
Case-Control Studies
Child
Gastroenteritis* / epidemiology
Humans
Inflammation
SARS-CoV-2