Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy

Matilda F Chan; Peipei Pan; Finn D Wolfreys

doi:10.1097/ICO.0000000000003292

Novel Mechanisms Guide Innovative Molecular-Based Therapeutic Strategies for Fuchs Endothelial Corneal Dystrophy

Cornea. 2023 Aug 1;42(8):929-933. doi: 10.1097/ICO.0000000000003292. Epub 2023 Jun 13.

Authors

Matilda F Chan^{1

2}, Peipei Pan³, Finn D Wolfreys¹

Affiliations

¹ Department of Ophthalmology, University of California, San Francisco, CA.
² Francis I. Proctor Foundation, University of California, San Francisco, CA; and.
³ Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA.

Abstract

Major advances in genomics have dramatically increased our understanding of Fuchs endothelial corneal dystrophy (FECD) and identified diverse genetic causes and associations. Biomarkers derived from these studies have the potential to inform both clinical treatment and yield novel therapeutics for this corneal dystrophy.

MeSH terms

Corneal Dystrophies, Hereditary*
Endothelium, Corneal
Fuchs' Endothelial Dystrophy* / genetics
Humans

Abstract

MeSH terms

Grants and funding