Succimer Mitigates the Perioperative Risk for an Increase in Blood Lead Levels During Bulletectomy: A Case Report

JBJS Case Connect. 2023 Jun 15;13(2). doi: 10.2106/JBJS.CC.23.00011. eCollection 2023 Apr 1.

Abstract

Case: A 38-year-old man with a tibial plateau fracture required treatment for elevated blood lead level (BLL) from retained bullet fragments in the same knee from a gunshot wound 21 years earlier. Oral succimer presurgery and postsurgery decreased the BLL from 58 to 15 μg/dL.

Conclusion: Parenteral chelation has been previously recommended to mitigate an increase in BLLs during surgical intervention to remove bullet fragments. Oral succimer was an effective and well-tolerated alternative to intravenous chelation. Further research is needed to determine the optimal route, timing, and duration of chelation in patients with elevated BLL in need of bulletectomy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chelating Agents
  • Humans
  • Lead
  • Lead Poisoning* / drug therapy
  • Lead Poisoning* / etiology
  • Male
  • Succimer
  • Wounds, Gunshot* / complications
  • Wounds, Gunshot* / surgery

Substances

  • Succimer
  • Lead
  • Chelating Agents