Bilateral anterior uveitis as a presenting feature of Juvenile Xanthogranuloma in a neonate

Brajesh Lahri; Zakir Hussain; Neerja Gupta; Shikha Gupta; Abhishek Singh; Viney Gupta

doi:10.1016/j.ajoc.2023.101867

Bilateral anterior uveitis as a presenting feature of Juvenile Xanthogranuloma in a neonate

Am J Ophthalmol Case Rep. 2023 Jun 3:31:101867. doi: 10.1016/j.ajoc.2023.101867. eCollection 2023 Sep.

Authors

Brajesh Lahri¹, Zakir Hussain¹, Neerja Gupta², Shikha Gupta¹, Abhishek Singh¹, Viney Gupta¹

Affiliations

¹ Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
² Department of Paediatrics, Genetics Division, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Abstract

Purpose: To report a case of diffuse xanthogranuloma presenting as bilateral anterior uveitis in a neonate.

Observations: A neonate was brought by the parents with complaints of redness, watering, and photophobia in both eyes for 10 days. Examination under anesthesia revealed the presence of bilateral hyphema, fibrinous membrane, corneal haze, and raised intraocular pressure (IOP). Ultrasound Biomicroscopy revealed diffuse bilateral iris thickening. The child was managed medically with topical glaucoma medications, topical steroids, and cycloplegics. The child responded well with the resolution of hyphema, anterior chamber inflammation, and reduction of IOP.

Conclusion and importance: In neonates and infants presenting with bilateral uveitis, spontaneous hyphema, and secondary glaucoma, even in the absence of a well-defined iris lesion, diffuse juvenile xanthogranuloma should be considered as a differential diagnosis.

Publication types

Case Reports