Not just snot: Local inflammatory profiles in patients with aspirin-exacerbated respiratory disease differ from patients with aspirin-tolerant chronic rhinosinusitis

Simon Chiang; Sophie E Yu; Tejas S Athni; Regan W Bergmark; Alice Z Maxfield; Rachel E Roditi; Kathleen M Buchheit; Marie Lundberg; Margaret B Mitchell; Stella E Lee

doi:10.1002/alr.23216

Not just snot: Local inflammatory profiles in patients with aspirin-exacerbated respiratory disease differ from patients with aspirin-tolerant chronic rhinosinusitis

Int Forum Allergy Rhinol. 2024 Jan;14(1):110-113. doi: 10.1002/alr.23216. Epub 2023 Jul 5.

Authors

Affiliations

¹ Division of Otolaryngology - Head & Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
² Center for Surgery and Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
³ Department of Medicine, Harvard Medical School, The Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, and the Jeff and Penny Vinik Center, Boston, Massachusetts, USA.
⁴ Department of Otolaryngology - Head & Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Abstract

IL-5, CCL2, and CXCL8 in sinus mucous are higher in patients with AERD relative to aspirin-tolerant patients with CRS These mediators are pleiotropic, leading to widescale inflammatory processes contributing to AERD AERD is not only a T2 disease but heterogeneous: this may explain the refractory nature of AERD.

Keywords: asthma; biomarker; chronic rhinosinusitis.

MeSH terms

Aspirin / adverse effects
Asthma, Aspirin-Induced*
Chronic Disease
Humans
Nasal Polyps*
Rhinitis*
Rhinosinusitis*
Sinusitis*

Substances

Aspirin

Grants and funding

T32 GM007753/GM/NIGMS NIH HHS/United States