Pancreatic cancer poses a challenge in healthcare and is one of a leading cause of cancer-related mortality. In 2021, around 1,000 new cases were diagnosed in Denmark. The disease itself is associated with a poor prognosis. Partly due to its silent nature and partly due to the lack of sensitive and specific tumour markers for early detection. The five-year survival rate among patients with pancreatic cancer in Denmark is 5-6%. I this review, we describe the current diagnostic and treatment options as well as the status on cancer-predictive biomarkers and their screening potential.