Mitral valve remodeling in the development of obstructive hypertrophic cardiomyopathy

Francesco Moroni; Abhishek Chaturvedi; Ehsan Jafree; Zachary M Gertz

doi:10.1016/j.ihj.2023.06.007

Mitral valve remodeling in the development of obstructive hypertrophic cardiomyopathy

Indian Heart J. 2023 Jul-Aug;75(4):308-310. doi: 10.1016/j.ihj.2023.06.007. Epub 2023 Jun 20.

Authors

Francesco Moroni¹, Abhishek Chaturvedi², Ehsan Jafree², Zachary M Gertz³

Affiliations

¹ VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA; The Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, USA.
² VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA.
³ VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: [email protected].

Abstract

Approximately 2/3 of patients with hypertrophic cardiomyopathy (HCM) have significant left ventricular outflow tract obstruction (LVOTO), which is caused by the interaction mitral valve apparatus and the hypertrophied septum. The contribution of mitral valve remodeling to the development of obstruction over time has never been described. We analyzed retrospectively 40 patients with HCM and no baseline obstruction followed up for a median of 2179 days. At follow up, 13 patients developed significant LVOTO. Patients who developed LVOTO had longer posterior leaflets and longer anterior leaflet residual length.

Keywords: Hypertrophic cardiomyopathy; Left ventricular tract obstruction; Mitral valve; Systolic anterior motion.

MeSH terms

Cardiomyopathy, Hypertrophic* / diagnosis
Humans
Mitral Valve / diagnostic imaging
Retrospective Studies
Ventricular Outflow Obstruction* / diagnosis
Ventricular Outflow Obstruction* / etiology
Ventricular Outflow Obstruction, Left*