Long non‑coding RNAs as potential therapeutic targets in non‑small cell lung cancer (Review)

Int J Mol Med. 2023 Aug;52(2):68. doi: 10.3892/ijmm.2023.5271. Epub 2023 Jun 23.

Abstract

Non‑small cell lung cancer (NSCLC) is one of the most common malignancies with a high morbidity and mortality rate. Long non‑coding RNAs (lncRNAs) have been reported to be closely associated with the occurrence and progression of NSCLC. In addition, lncRNAs have been documented to participate in the development of drug resistance and radiation sensitivity in patients with NSCLC. Due to their extensive functional characterization, high tissue specificity and sex specificity, lncRNAs have been proposed to be novel biomarkers and therapeutic targets for NSCLC. Therefore, in the current review, the functional classification of lncRNAs were presented, whilst the potential roles of lncRNAs in NSCLC were also summarized. Various physiological aspects, including proliferation, invasion and drug resistance, were all discussed. It is anticipated that the present review will provide a perspective on lncRNAs as potential diagnostic molecular biomarkers and therapeutic targets for NSCLC.

Keywords: NSCLC; biomarkers; drug resistance; lncRNA; therapeutic targets.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Carcinoma, Non-Small-Cell Lung* / drug therapy
  • Carcinoma, Non-Small-Cell Lung* / genetics
  • Carcinoma, Non-Small-Cell Lung* / pathology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics
  • Lung Neoplasms* / pathology
  • RNA, Long Noncoding* / genetics

Substances

  • RNA, Long Noncoding
  • Biomarkers, Tumor

Grants and funding

The present study was supported by the National Natural Science Foundation of China (NSFC) (grant no. 82204224), the Chunhui Program-Cooperative Research Project of the Ministry of Education, Liaoning Natural Science Foundation (grant no. 2022-MS-241), the China Postdoctoral Science Foundation (grant no. 2021M693957), the Shenyang Young and Middle-aged Innovative Talents Support Program (grant no. RC210446), and the Project of the Educational Department of Liaoning (grant no. LJKZ0919).