Abstract
The present study provides the first information on the chemical composition and acetylcholinesterase inhibitory activity of the essential oil (EO) from the leaves of Mitrephora poilanei Weeras. & R.M.K.Saunders from Vietnam. Gas chromatography and gas chromatography-mass spectrometry analysis revealed that the main components of the M. poilanei EO were β-caryophyllene (13.2%), α-humulene (10.5%), germacrene D (8.1%), β-elemene (5.2%) and bicyclogermacrene (5.1%). The anti-acetylcholinesterase assay showed that the EO displayed moderate activity with IC50 value of 31.16 ± 3.06 μg/mL. These findings proposed that the plant can be exploited for its anti-acetylcholinestrate potential.
Keywords:
AChE; IC50; Mitrephora poilanei; terpenes; β-caryophyllene.
MeSH terms
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Acetylcholinesterase / drug effects
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Acetylcholinesterase / metabolism
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / pharmacology
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Gas Chromatography-Mass Spectrometry
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Monocyclic Sesquiterpenes / chemistry
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Monocyclic Sesquiterpenes / pharmacology
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Oils, Volatile* / chemistry
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Oils, Volatile* / pharmacology
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Plant Leaves* / chemistry
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Polycyclic Sesquiterpenes* / chemistry
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Polycyclic Sesquiterpenes* / pharmacology
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Sesquiterpenes* / chemistry
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Sesquiterpenes* / pharmacology
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Sesquiterpenes, Germacrane / chemistry
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Sesquiterpenes, Germacrane / pharmacology
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Vietnam
Substances
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Acetylcholinesterase
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beta-elemene
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caryophyllene
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Cholinesterase Inhibitors
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germacrene D
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humulene
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Monocyclic Sesquiterpenes
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Oils, Volatile
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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Sesquiterpenes, Germacrane