Atomic-precise Pt2Cu4 cluster-based fluorescent sensor for rapid interleukin-6 detection

Zi-Hui Shao; Hui-Lin Mo; Xueli Zhao; Fuwei Xie; Ge Zhao

doi:10.1039/d3ay00642e

Atomic-precise Pt₂Cu₄ cluster-based fluorescent sensor for rapid interleukin-6 detection

Anal Methods. 2023 Jul 6;15(26):3161-3164. doi: 10.1039/d3ay00642e.

Authors

Zi-Hui Shao¹, Hui-Lin Mo¹, Xueli Zhao¹, Fuwei Xie², Ge Zhao²

Affiliations

¹ Henan Key Laboratory of Crystalline Molecular Functional Materials, Henan International Joint Laboratory of Tumor Theranostic Cluster Materials, Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. [email protected].
² Zhengzhou Tobacco Research Institute of CNTC, No. 2 of Fengyang Street, Zhengzhou, 450001, China. [email protected].

PMID: 37357698
DOI: 10.1039/d3ay00642e

Abstract

Levonorgestrel protected Pt₂Cu₄ clusters were assembled with a polymer to prepare nanobeads (NBs) with intense red fluorescence. An immunofluorescence sensor based on Pt₂Cu₄NBs was established for the rapid and sensitive detection of interleukin-6 (IL-6) owing to its significance in inflammatory diseases, with a limit of detection of 42.66 pg mL^-1. IL-6 spiked in serum was also accurately detected.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Copper / chemistry
Fluorescent Dyes / chemistry
Interleukin-6 / analysis
Platinum Compounds* / chemistry

Substances

Copper
Platinum Compounds
Fluorescent Dyes
Interleukin-6