The polymorphisms of miR-146a SNPs are associated with asthma in Southern Chinese Han population

Yisen Cheng; Qiqi Tang; Yu Li; Xusan Xu; Xiangfan Zhen; Ning Chang; Si Huang; Jieqing Zeng; Fei Luo; Qianqian Ouyang; Liuquan Peng; Guoda Ma; Yajun Wang

doi:10.1016/j.gene.2023.147587

The polymorphisms of miR-146a SNPs are associated with asthma in Southern Chinese Han population

Gene. 2023 Aug 30:879:147587. doi: 10.1016/j.gene.2023.147587. Epub 2023 Jun 25.

Authors

Yisen Cheng¹, Qiqi Tang², Yu Li², Xusan Xu², Xiangfan Zhen², Ning Chang², Si Huang², Jieqing Zeng², Fei Luo², Qianqian Ouyang³, Liuquan Peng⁴, Guoda Ma⁵, Yajun Wang⁶

Affiliations

¹ Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Foshan 528300, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China; School of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530000, China.
² Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Foshan 528300, China.
³ The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Guangdong Medical University, Zhanjiang 524023, China.
⁴ Department of Pediatrics, Shunde Women and Children's Hospital of Guangdong Medical University, Foshan 528300, China.
⁵ Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Foshan 528300, China; The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China; Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan 528300, China. Electronic address: [email protected].
⁶ Maternal and Children's Health Research Institute, Shunde Maternal and Children's Hospital, Guangdong Medical University, Foshan 528300, China; Clinical Research Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China. Electronic address: [email protected].

PMID: 37364699
DOI: 10.1016/j.gene.2023.147587

Abstract

Asthma, a prevalent disease characterized by innate and adaptive immune responses, has been associated with several risk factors including miR-146a. To better understand the potential impact of miR-146a SNPs on asthma susceptibility and clinical features in Southern Chinese Han population, we conducted a case-control to analyze two functional SNPs (rs2910164 and rs57095329) of the miR-146a (394 patients with asthma and 395 healthy controls). Our findings suggest that the rs2910164 C/G genotype may increase the risk for asthma in females, while the rs57095329 G/G genotype may be involved in the regulation of clinical characteristics of males with asthma. In addition, we demonstrated that the SNPs rs2910164 C/G and rs57095329 A/G variations functionally affected the miR-146a levels in patients with asthma, and may alter structure of miR-146a. Our data are the first to suggest that miR-146a SNPs may be significantly associated with onset asthma in Southern Chinese Han population. Our studies may provide new insight into the potential significance of miR-146a SNPs in asthma.

Keywords: Asthma; SNPs; microRNA-146a(miR-146a).

MeSH terms

Case-Control Studies
East Asian People
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
MicroRNAs* / genetics
Polymorphism, Single Nucleotide*

Substances

MicroRNAs
MIRN146 microRNA, human