Local cytokine levels associate with SNOT-22 and UPSIT scores in chronic rhinosinusitis

Sophie E Yu; Simon Chiang; Tolani F Olonisakin; John A Moore; Regan W Bergmark; Alice Z Maxfield; Rachel E Roditi; Kathleen M Buchheit; Marie Lundberg; Margaret B Mitchell; Stella E Lee

doi:10.1002/alr.23222

Local cytokine levels associate with SNOT-22 and UPSIT scores in chronic rhinosinusitis

Int Forum Allergy Rhinol. 2024 Jan;14(1):114-118. doi: 10.1002/alr.23222. Epub 2023 Jul 11.

Authors

Affiliations

¹ Division of Otolaryngology - Head & Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
² Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA.
³ Department of Otolaryngology-Head & Neck Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
⁴ Center for Surgery and Public Health, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁵ Division of Allergy and Clinical Immunology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁶ Department of Otolaryngology - Head & Neck Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

PMID: 37365846
DOI: 10.1002/alr.23222

Abstract

Elevated IL-5, IL-13, IL-33, and CCL2 correlate with lower UPSIT scores in CRS and AERD patients. Elevated IL-5, IL-13, TNF-α, CCL2, and CXCL-8 correlate with higher SNOT-22 scores in CRS and AERD patients.

Keywords: 22-item Sino-Nasal Outcome Test (SNOT-22); Lund-Kennedy (LK); University of Pennsylvania Smell Identification Test (UPSIT); chronic rhinosinusitis (CRS); endotype; patient-reported outcome measures (PROM).

MeSH terms

Chronic Disease
Cytokines
Humans
Interleukin-13
Interleukin-5
Nasal Polyps*
Rhinitis* / diagnosis
Rhinosinusitis*
Sino-Nasal Outcome Test
Sinusitis* / diagnosis

Substances

Cytokines
Interleukin-13
Interleukin-5