In this news and views, we discuss our recent publication where we described how ER-PM membrane contact sites (MCS) are modulated during store operated calcium entry (SOCE). We also examine why enforcing ER-PM MCS by tethering proteins does not not enhance, but rather inhibits SOCE.
Keywords: electron microscopy; endoplasmic reticulum; plasma membrane; store-operated calcium entry (SOCE) (SOC); tether.
© The Author(s) 2023.