An engineered xCas12i with high activity, high specificity, and broad PAM range
Protein Cell
.
2023 Jun 28;14(7):538-543.
doi: 10.1093/procel/pwac052.
Authors
Hainan Zhang
1
,
Xiangfeng Kong
1
,
Mingxing Xue
1
,
Jing Hu
1
,
Zikang Wang
1
,
Yinghui Wei
1
,
Haoqiang Wang
1
,
Jingxing Zhou
1
,
Weihong Zhang
1
,
Mengqiu Xu
1
,
Xiaowen Shen
1
,
Fengcai Yin
1
,
Zhiyuan Ai
1
,
Guangyan Huang
1
,
Junhui Xia
1
,
Xueqiong Song
1
,
Hengbin Li
2
,
Yuan Yuan
2
,
Jinhui Li
1
,
Na Zhong
1
,
Meiling Zhang
3
,
Yingsi Zhou
1
,
Hui Yang
1
2
Affiliations
1
HuiEdit Therapeutics Co., Ltd., Shanghai 200120, China.
2
HuiGene Therapeutics Co., Ltd., Shanghai 200120, China.
3
Center for Reproductive Medicine, International Peace Maternity and Child Health Hospital, Innovative Research Team of High-level Local Universities in Shanghai, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
PMID:
37378659
PMCID:
PMC10305737
DOI:
10.1093/procel/pwac052
No abstract available
Publication types
Research Support, Non-U.S. Gov't
MeSH terms
CRISPR-Associated Protein 9*
CRISPR-Cas Systems / genetics
Gene Editing*
Substances
CRISPR-Associated Protein 9