Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias

Affiliations

• ¹ Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
• ² Neuromuscular Diseases Research Section, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
• ³ Computational Biology Group, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
• ⁴ Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY, USA.
• ⁵ Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, USA.
• ⁶ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
• ⁷ Program in Medical and Population Genetics, Broad Institute of Massachusetts Institute of Technology (M.I.T.), Cambridge, MA, USA.
• ⁸ Division of Medical Sciences and Department of Medicine, Harvard Medical School, Boston, MA, USA.
• ⁹ Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
• ¹⁰ Centre for Alzheimer's and Related Dementias, National Institute on Aging, Bethesda, MD, USA.
• ¹¹ Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
• ¹² Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
• ¹³ Neuroregeneration and Stem Cell Programs, Institute of Cell Engineering, Johns Hopkins University Medical Center, Baltimore, MD, USA.
• ¹⁴ Department of Pharmacology and Molecular Science, Johns Hopkins University Medical Center, Baltimore, MD, USA.
• ¹⁵ Solomon H. Snyder Department of Neuroscience, Johns Hopkins University Medical Center, Baltimore, MD, USA.
• ¹⁶ Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University of Buffalo, Buffalo, NY, USA.
• ¹⁷ Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA.
• ¹⁸ Cognitive & Movement Disorders Clinic, Sunnybrook Health Sciences Centre, University of Toronto, 1 King's College Circle, Room 2374, Toronto, ON, Canada.
• ¹⁹ Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
• ²⁰ Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, University of Toronto, 2075 Bayview Avenue, Toronto, ON, Canada.
• ²¹ LC Campbell Cognitive Neurology Research Unit, Sunnybrook Research Institute, University of Toronto, 2075 Bayview Avenue, Toronto, ON, Canada.
• ²² Department of Anatomical Pathology, Sunnybrook Health Sciences Centre, University of Toronto, 1 King's College Circle, Room 2374, Toronto, ON, Canada.
• ²³ Institute of Medical Science, Faculty of Medicine, University of Toronto, 1 King's College Circle, Room 2374, Toronto, ON, Canada.
• ²⁴ Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Sunnybrook Health Sciences Centre, University of Toronto, 1 King's College Circle, Room 2374, Toronto, ON, Canada.
• ²⁵ Longitudinal Studies Section, National Institute on Aging, Baltimore, MD, USA.
• ²⁶ Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
• ²⁷ Scripps Research Translational Institute, Scripps Research, La Jolla, CA, USA.
• ²⁸ Translational Immunology, Research Programs Unit, University of Helsinki, Helsinki, Finland.
• ²⁹ Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
• ³⁰ Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
• ³¹ Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
• ³² Department of Neurology, University of Massachusetts Medical School, Worcester, MA, USA.
• ³³ Department of Genetics and Genomic Medicine Research & Teaching, UCL GOS Institute of Child Health, University College London, London, UK.
• ³⁴ Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK.
• ³⁵ NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London, London, UK.
• ³⁶ Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
• ³⁷ UCL Movement Disorders Centre, University College London, London, UK.
• ³⁸ UK Dementia Research Institute, Department of Neurogenerative Disease and Reta Lila Weston Institute, London, UK.
• ³⁹ Institute of Advanced Study, The Hong Kong University of Science and Technology, Hong Kong SAR, China.
• ⁴⁰ Maggiore della Carita University Hospital, Novara, Italy.
• ⁴¹ Department of Health Sciences, University of Eastern Piedmont, Novara, Italy.
• ⁴² Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy.
• ⁴³ Azienda Ospedaliero Universitaria Città, della Salute e della Scienza, Corso Bramante, 88, Turin, Italy.
• ⁴⁴ Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.
• ⁴⁵ Department of Psychiatry and Psychology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, USA.
• ⁴⁶ Department of Neurology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, USA.
• ⁴⁷ Center for Sleep Medicine, Mayo Clinic, Rochester, MN, USA.
• ⁴⁸ Institute of Cognitive Sciences and Technologies, C.N.R., Via S. Martino della Battaglia, 44, Rome, Italy.
• ⁴⁹ Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
• ⁵⁰ Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
• ⁵¹ The American Genome Center, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
• ⁵² RNA Therapeutics Laboratory, Therapeutics Development Branch, National Center for Advancing Translational Sciences, Rockville, MD, USA.