Cardiac Complications of Pregnancy in Desmoplakin Cardiomyopathy

Madeline E Duncan; Anisha Purohit; Katherine E Economy; Anne Marie Valente; Neal K Lakdawala

doi:10.1016/j.jaccas.2023.101880

Cardiac Complications of Pregnancy in Desmoplakin Cardiomyopathy

JACC Case Rep. 2023 May 13:16:101880. doi: 10.1016/j.jaccas.2023.101880. eCollection 2023 Jun 21.

Authors

Madeline E Duncan^{1

2}, Anisha Purohit³, Katherine E Economy⁴, Anne Marie Valente^{1

2

3}, Neal K Lakdawala³

Affiliations

¹ Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts, USA.
² Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
³ Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁴ Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Abstract

We present the course of 4 pregnancies in 3 women with desmoplakin cardiomyopathy, with a focus on changes in left ventricular ejection fraction and N-terminal pro-B-type natriuretic peptide levels from the prepregnancy period through the postpartum period, as well as maternal cardiac, obstetric, and neonatal outcomes. (Level of Difficulty: Advanced.).

Keywords: arrhythmogenic cardiomyopathy; cardio-obstetrics; desmoplakin; pregnancy.

Publication types

Case Reports